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TheodoreSmith-FirstPaper 14 - 09 Jan 2009 - Main.TheodoreSmith
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Placing Molecular Compounds in the Public Domain

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 Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines would likely be even simpler to develop.
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Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecule, such as H2O, can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.
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Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecules, such as H2O, can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.
 The combination of trivial enablement and a finite structure would place chemical compounds within a unique class respective to patent law. A full description and build routine of a novel compound could be generated from a small amount of descriptive data, in some cases as little as a name.

The Internet Is for Publishing

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Legally, the trivialization of the enablement of molecular compounds is likely to cause the most disruption within the patent doctrine of novelty. Under novelty rules, a patent may be invalidated by published prior art that both describes and enables the claims of the patent. In the field of chemistry, the creation of invalidating prior art has historically been expensive; the synthesis of a novel chemical compound is research intensive, and the cost to physically publish the information is non-trivial.
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Legally, the trivialization of the enablement of molecular compounds is likely to cause the most disruption within the patent doctrine of novelty. Under novelty rules, a patent may be invalidated by published prior art that both describes and enables the claims of the patent. In the field of chemistry, the creation of invalidating prior art has historically been expensive: the synthesis of a novel chemical compound is research intensive, and the cost to physically publish the information is non-trivial.
 Historically, we may look at this expense as having two important effects. First, it sets the cost of generating invalidating prior art close to the cost of the research necessary to actually file a patent. Second, it makes the cost of filing a patent cheaper relative to the amount of capital spent on research and development. These ratios have encouraged the development of patents over the generation of public prior art; they have decreased the marginal cost of seeking a patent over simply publishing information into the public domain.

TheodoreSmith-FirstPaper 13 - 15 Nov 2008 - Main.EbenMoglen
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Placing Molecular Compounds in the Public Domain

-- By TheodoreSmith - 18 Oct 2008

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 Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines would likely be even simpler to develop.
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Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecule, such as H2O? , can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.
>
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Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecule, such as H2O, can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.
 The combination of trivial enablement and a finite structure would place chemical compounds within a unique class respective to patent law. A full description and build routine of a novel compound could be generated from a small amount of descriptive data, in some cases as little as a name.
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Conclusion

Although a precise legal and technical investigation remains outside the scope of this paper, it is important to note that this analysis rests not on the details of the implementation or technologies used, but on the fundamental characteristics of molecular compounds, the internet, and patent law. Similarly, it should be recognized that this change is not manifestly positive or negative. Although an economic or moral analysis of the shift may be useful in providing context, such judgments have no effect on the inevitability of the change; the cost efficiencies of internet publication and cheap computational power all but guarantee the eventual outcome.

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I think this is a superb example of thinking realistically over the horizon. It would not have been sensible in 1,000 words--while introducing concepts abtruse for many (which in my view you do with clarity and economy)--to have imagined the possible legislative responses likely from an industry with so much to lose from loss of patentability. But further meditation on that line might be fruitful.

-- EbenMoglen - 15 Nov 2008

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TheodoreSmith-FirstPaper 12 - 09 Nov 2008 - Main.TheodoreSmith
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THIS IS A WORK IN PROGRESS

 
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Placing Organic Chemical Compounds in the Public Domain

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Placing Molecular Compounds in the Public Domain

 -- By TheodoreSmith - 18 Oct 2008
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 Legally, the trivialization of the enablement of molecular compounds is likely to cause the most disruption within the patent doctrine of novelty. Under novelty rules, a patent may be invalidated by published prior art that both describes and enables the claims of the patent. In the field of chemistry, the creation of invalidating prior art has historically been expensive; the synthesis of a novel chemical compound is research intensive, and the cost to physically publish the information is non-trivial.
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Historically, we may look at this expense as having two important effects. First, it sets the cost of generating invalidating prior art close to the cost of the research necessary to actually file a patent. Second, it makes the cost of filing a patent cheaper relative to the amount of capital spent on research and development. These ratios encourage the development of patents over the generation of public prior art; they decrease the marginal cost of seeking a patent over simply publishing information into the public domain.
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Historically, we may look at this expense as having two important effects. First, it sets the cost of generating invalidating prior art close to the cost of the research necessary to actually file a patent. Second, it makes the cost of filing a patent cheaper relative to the amount of capital spent on research and development. These ratios have encouraged the development of patents over the generation of public prior art; they have decreased the marginal cost of seeking a patent over simply publishing information into the public domain.
 With the trivialization of the enablement step and the advent of near-zero-cost publishing on the internet, both these ratios shift substantially. A public internet wiki with computationally inexpensive algorithms for permuting and enabling molecular structures drops the cost of publishing invalidating prior art to nearly nothing. The invalidating enablement steps and published description that would have taken a chemist years to produce may be generated and published in the US for fractions of a cent by anyone on earth; a bored high school student playing around with chemical structures on such a wiki during class could produce and publish invalidating prior art covering thousands of molecular permutations. Although the brute force publishing of all possible permutations of all feasible molecular structures is likely impossible, and the pharmaceutical companies will likely retain some unexplored patent space in which to work, the balance between between the public and the patentable will have forever changed.

TheodoreSmith-FirstPaper 11 - 09 Nov 2008 - Main.TheodoreSmith
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THIS IS A WORK IN PROGRESS

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Introduction

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Chemical compounds are protected under US patent law as "compositions of matter." A successful compound patent will provide the inventor with exclusive rights to all uses of that composition (including research) over the life of the patent. Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure of the molecule and "enablement", a means of successfully building or synthesizing the chemical; no showing of usefulness is required. As advances in the material sciences refine techniques for the atomic level manipulation of matter, we are rapidly nearing the point where enablement of a given organic compound becomes trivial; any organic molecule may be constructed from its constituent atoms or pre-synthesized building blocks.
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Chemical compounds are protected under US patent law as "compositions of matter." Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure of the molecule and "enablement," a means of successfully building or synthesizing the chemical; no showing of usefulness is required. As advances in the material sciences refine techniques for the atomic level manipulation of matter, we are rapidly nearing the point where enablement becomes trivial; any organic molecule may be constructed from its constituent atoms or pre-synthesized building blocks.
 
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Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a wiki-style database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would theoretically have the effect of rendering unpatentable every compound appearing within.
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Once this threshold is reached, new chemical compositions will become far easier to push into the public domain. Even if such novel compounds do not become generally unpatentable under the doctrine of obviousness, it will become possible to render them unpatentable simply by publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a wiki-style database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential compounds, would have the effect of rendering unpatentable every molecule appearing within.
 
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Enablement and Scanning Electron Microscopes

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Enablement and STMs

 
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Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a 2002 paper, Hla and Reider detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel molecular structures. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last 19 years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the breaking and reforming of bonds within a molecule itself; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality.
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Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a 2002 paper, Hla and Reider detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel compounds. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last 19 years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the breaking and reforming of bonds within a molecule itself; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality.
 
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The Strange Properties of Molecules

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Strange Properties of Molecules

 
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Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines for chemical structures would likely be even simpler to develop.
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Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines would likely be even simpler to develop.
 Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecule, such as H2O? , can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.
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The combination of trivial enablement and a finite structure would place chemical compounds within an unique class respective to patent law. A full description and build routine of a novel compound could be generated from a small amount of descriptive data, in some cases as little as a name.
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The combination of trivial enablement and a finite structure would place chemical compounds within a unique class respective to patent law. A full description and build routine of a novel compound could be generated from a small amount of descriptive data, in some cases as little as a name.
 
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Legal Ramifications of Trivial Enablement

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The Internet Is for Publishing

 
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Legally, the trivialization of the enablement of molecular compounds is likely to cause the most disruption within the patent doctrines of obviousness and novelty.
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Legally, the trivialization of the enablement of molecular compounds is likely to cause the most disruption within the patent doctrine of novelty. Under novelty rules, a patent may be invalidated by published prior art that both describes and enables the claims of the patent. In the field of chemistry, the creation of invalidating prior art has historically been expensive; the synthesis of a novel chemical compound is research intensive, and the cost to physically publish the information is non-trivial.
 
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Of these two doctrines, obviousness is the least likely to be disruptive to the patentability of molecular compounds. Although it could be argued that the combination of trivial enablement and computationally accessible discrete structures make nearly any chemical compound "obvious ... to a person having ordinary skill in the art to which said subject matter pertains," and therefore unpatentable, it is unlikely, given the history and economic importance of these patents, that either the Patent Office or the Federal Courts would accept such arguments.

The doctrine of novelty is likely to affect the patentability of chemical compounds in a far more profound manner. Under the novelty rules, a patent may be invalidated by published prior art that both describes and enables the claims of the patent. In the field of chemistry, the creation of invalidating prior art has historically been expensive; the synthesis of a novel chemical compound is research intensive, and the cost to physically publish the information is non-trivial.

Historically, we may look at this expense as having two important effects. First, it sets the cost of generating invalidating prior art close to the cost of doing the research necessary to actually file a patent. Although filing a patent requires additional research into the usefulness of the compound, this is unlikely to cost orders of magnitude more than the research necessary for synthesis. Second, it has made the actual cost of filing the patent, while non-trivial, cheaper in relation to the amounts of capital spent on research and development. These ratios encourage the development of patents, as opposed to the generation of public prior art; both ratios decrease the marginal cost of applying for a patent over simply publishing information into the public domain.

With the trivialization of the enablement step and the advent of near-zero-cost publishing on the internet, both these ratios shift substantially. A public internet wiki with computationally inexpensive algorithms for permuting and enabling molecular structures drops the cost of publishing invalidating prior art to nearly nothing. Although a pharmaceutical company may

The identification of interesting compounds, however the

, has been nearly For the purposes of this essay, this historical expense is interesting because of two ratios. The first ratio describes the cost of developing and publishing invalidating prior art versus doing the research necessary to actually file a patent. Historically, these costs have generally been of similar magnitudes; although a patent requires additional research into the usefulness of the compound, any demonstrated use will suffice to fulfill th

is the With computationally cheap methods of generating descriptions

Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.

Other forms of Patent Protection

A database of structures and build routines would have the effect of placing many future compound patents into the public domain. Instructions enabling the individual construction of organic molecules could also be argued to invalidate future “purification” patents on molecules within the database; enabling the construction of an individual molecule would have the effect of enabling (very small-scale) production of purified forms of the compound, and would prevent corporations from later claiming that they had newly purified extant substances.

The type of enablement database described in this essay would have no effect on two alternative forms of patent protection: the use patent, and the production patent. The use patent provides exclusive rights over a particular use of a compound, regardless of the legal ownership status of the compound itself. Although use rights are far more limited and difficult to enforce than patents on the compound itself, there is nothing fundamental to the nature of the database itself that would prevent this type of patent.

The enablement database would likewise have no effect on production patents – methods of synthesizing or otherwise producing the molecule. Although the particular production steps in the atomic level build routine would be in the public domain, commercially viable methods of manufacturing the molecule would be available for patent protection.

Neither of these alternate forms of patent protection would be diminished or eliminated by the existence of a public enablement database; however, a public commons could easily be created within a public internet database, simply by adding wiki-like features to the site itself. By providing a place for the posting and discussion of information surrounding

Technical and Legal Issues to be Overcome

Many permutations of chemical compounds – could we have in a database, or would an algorithm suffice – mixed so that requesting a molecule would create a permanent entry in a database. Corporations forming their own databases to gain rights (the one case that does not require uses), BUT look at statutory bars and diligence. Alternately, this may allow purification patenting by corporations, and the fact that the use requirement is set so low may lead to a rush of corporate patents before compounds enter the public domain. They would be potentially be able to patent more stuff, but it would be the final rush – 21 years, and all such compounds would be in the public domain.

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Historically, we may look at this expense as having two important effects. First, it sets the cost of generating invalidating prior art close to the cost of the research necessary to actually file a patent. Second, it makes the cost of filing a patent cheaper relative to the amount of capital spent on research and development. These ratios encourage the development of patents over the generation of public prior art; they decrease the marginal cost of seeking a patent over simply publishing information into the public domain.
 
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With the trivialization of the enablement step and the advent of near-zero-cost publishing on the internet, both these ratios shift substantially. A public internet wiki with computationally inexpensive algorithms for permuting and enabling molecular structures drops the cost of publishing invalidating prior art to nearly nothing. The invalidating enablement steps and published description that would have taken a chemist years to produce may be generated and published in the US for fractions of a cent by anyone on earth; a bored high school student playing around with chemical structures on such a wiki during class could produce and publish invalidating prior art covering thousands of molecular permutations. Although the brute force publishing of all possible permutations of all feasible molecular structures is likely impossible, and the pharmaceutical companies will likely retain some unexplored patent space in which to work, the balance between between the public and the patentable will have forever changed.
 

Conclusion

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An economic or moral analysis of this change is beyond the scope of this paper. Chemical compounds have two important characteristics that make them vulnerable to advances: They have a concrete and definite structure – it is more difficult to write an amorphous business method or algorithm style claim to escape the restrictions of prior art, and they are finite in potential size – NEED DATA.
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Although a precise legal and technical investigation remains outside the scope of this paper, it is important to note that this analysis rests not on the details of the implementation or technologies used, but on the fundamental characteristics of molecular compounds, the internet, and patent law. Similarly, it should be recognized that this change is not manifestly positive or negative. Although an economic or moral analysis of the shift may be useful in providing context, such judgments have no effect on the inevitability of the change; the cost efficiencies of internet publication and cheap computational power all but guarantee the eventual outcome.

TheodoreSmith-FirstPaper 10 - 09 Nov 2008 - Main.TheodoreSmith
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THIS IS A WORK IN PROGRESS

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The Strange Properties of Molecules

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Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines for known chemical structures would likely be even simpler to develop.
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Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines for chemical structures would likely be even simpler to develop.
 Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecule, such as H2O? , can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.
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 Of these two doctrines, obviousness is the least likely to be disruptive to the patentability of molecular compounds. Although it could be argued that the combination of trivial enablement and computationally accessible discrete structures make nearly any chemical compound "obvious ... to a person having ordinary skill in the art to which said subject matter pertains," and therefore unpatentable, it is unlikely, given the history and economic importance of these patents, that either the Patent Office or the Federal Courts would accept such arguments.
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The doctrine of novelty is likely to affect the patentability of chemical compounds in a far more profound manner. Under the novelty rules, a patent may be invalidated by published prior art that both describes and enables the claims of the patent. In the field of chemistry, the creation of invalidating prior art has historically been expensive; the synthesis of a novel chemical compound is research intensive, and the cost to physically publish the information is non-trivial.

Historically, we may look at this expense as having two important effects. First, it sets the cost of generating invalidating prior art close to the cost of doing the research necessary to actually file a patent. Although filing a patent requires additional research into the usefulness of the compound, this is unlikely to cost orders of magnitude more than the research necessary for synthesis. Second, it has made the actual cost of filing the patent, while non-trivial, cheaper in relation to the amounts of capital spent on research and development. These ratios encourage the development of patents, as opposed to the generation of public prior art; both ratios decrease the marginal cost of applying for a patent over simply publishing information into the public domain.

With the trivialization of the enablement step and the advent of near-zero-cost publishing on the internet, both these ratios shift substantially. A public internet wiki with computationally inexpensive algorithms for permuting and enabling molecular structures drops the cost of publishing invalidating prior art to nearly nothing. Although a pharmaceutical company may

The identification of interesting compounds, however the

, has been nearly For the purposes of this essay, this historical expense is interesting because of two ratios. The first ratio describes the cost of developing and publishing invalidating prior art versus doing the research necessary to actually file a patent. Historically, these costs have generally been of similar magnitudes; although a patent requires additional research into the usefulness of the compound, any demonstrated use will suffice to fulfill th

is the With computationally cheap methods of generating descriptions

 Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.

Other forms of Patent Protection


TheodoreSmith-FirstPaper 9 - 08 Nov 2008 - Main.TheodoreSmith
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THIS IS A WORK IN PROGRESS

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 Chemical compounds are protected under US patent law as "compositions of matter." A successful compound patent will provide the inventor with exclusive rights to all uses of that composition (including research) over the life of the patent. Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure of the molecule and "enablement", a means of successfully building or synthesizing the chemical; no showing of usefulness is required. As advances in the material sciences refine techniques for the atomic level manipulation of matter, we are rapidly nearing the point where enablement of a given organic compound becomes trivial; any organic molecule may be constructed from its constituent atoms or pre-synthesized building blocks.
Changed:
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Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a wiki-style database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would have the effect of rendering unpatentable every compound appearing within.
>
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Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a wiki-style database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would theoretically have the effect of rendering unpatentable every compound appearing within.
 

Enablement and Scanning Electron Microscopes

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 Legally, the trivialization of the enablement of molecular compounds is likely to cause the most disruption within the patent doctrines of obviousness and novelty.
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Of these two doctrines, obviousness is the least likely to be disruptive to the patentability of molecular compounds. Although it could be argued that the combination of trivial enablement and computationally accessible discrete structures make nearly any chemical compound "obvious ... to a person having ordinary skill in the art to which said subject matter pertains," and therefore unpatentable, it is unlikely, given the history and economic importance of these patents, that either the Patent Office or the Federal Courts would accept such arguments.
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Of these two doctrines, obviousness is the least likely to be disruptive to the patentability of molecular compounds. Although it could be argued that the combination of trivial enablement and computationally accessible discrete structures make nearly any chemical compound "obvious ... to a person having ordinary skill in the art to which said subject matter pertains," and therefore unpatentable, it is unlikely, given the history and economic importance of these patents, that either the Patent Office or the Federal Courts would accept such arguments.
 Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.

TheodoreSmith-FirstPaper 8 - 30 Oct 2008 - Main.TheodoreSmith
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META TOPICPARENT name="WebHome"

THIS IS A WORK IN PROGRESS

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 Chemical compounds are protected under US patent law as "compositions of matter." A successful compound patent will provide the inventor with exclusive rights to all uses of that composition (including research) over the life of the patent. Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure of the molecule and "enablement", a means of successfully building or synthesizing the chemical; no showing of usefulness is required. As advances in the material sciences refine techniques for the atomic level manipulation of matter, we are rapidly nearing the point where enablement of a given organic compound becomes trivial; any organic molecule may be constructed from its constituent atoms or pre-synthesized building blocks.
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Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would have the effect of rendering unpatentable every compound appearing within.
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Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a wiki-style database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would have the effect of rendering unpatentable every compound appearing within.
 

Enablement and Scanning Electron Microscopes

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Legal Ramifications of Trivial Enablement

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Legally, the trivialization of the enablement step could
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Legally, the trivialization of the enablement of molecular compounds is likely to cause the most disruption within the patent doctrines of obviousness and novelty.

Of these two doctrines, obviousness is the least likely to be disruptive to the patentability of molecular compounds. Although it could be argued that the combination of trivial enablement and computationally accessible discrete structures make nearly any chemical compound "obvious ... to a person having ordinary skill in the art to which said subject matter pertains," and therefore unpatentable, it is unlikely, given the history and economic importance of these patents, that either the Patent Office or the Federal Courts would accept such arguments.

 Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.

TheodoreSmith-FirstPaper 7 - 30 Oct 2008 - Main.TheodoreSmith
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THIS IS A WORK IN PROGRESS

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 Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a 2002 paper, Hla and Reider detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel molecular structures. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last 19 years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the breaking and reforming of bonds within a molecule itself; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality.
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Losing Enablement

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The Strange Properties of Molecules

 
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Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines for known chemical structures would likely be even simpler to develop.
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Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines for known chemical structures would likely be even simpler to develop.
 Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecule, such as H2O? , can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.
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The combination of trivial enablement and a finite structure would place chemical compounds in an unique class of material, respective to patent law. Simply by naming a
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The combination of trivial enablement and a finite structure would place chemical compounds within an unique class respective to patent law. A full description and build routine of a novel compound could be generated from a small amount of descriptive data, in some cases as little as a name.

Legal Ramifications of Trivial Enablement

Legally, the trivialization of the enablement step could

 Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.

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THIS IS A WORK IN PROGRESS

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Introduction

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Chemical compounds are protected under US patent law as "compositions of matter." &lt cite needed &gt. A successful compound patent will provide the inventor with exclusive rights to all uses of that composition (including research) over the life of the patent. Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure of the molecule and "enablement", a means of successfully building or synthesizing the chemical; no showing of usefulness is required. As advances in the material sciences refine techniques for the atomic level manipulation of matter, we are rapidly nearing the point where enablement of a given organic compound becomes trivial; any organic molecule may be constructed from its constituent atoms or pre-synthesized building blocks.
>
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Chemical compounds are protected under US patent law as "compositions of matter." A successful compound patent will provide the inventor with exclusive rights to all uses of that composition (including research) over the life of the patent. Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure of the molecule and "enablement", a means of successfully building or synthesizing the chemical; no showing of usefulness is required. As advances in the material sciences refine techniques for the atomic level manipulation of matter, we are rapidly nearing the point where enablement of a given organic compound becomes trivial; any organic molecule may be constructed from its constituent atoms or pre-synthesized building blocks.
 Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would have the effect of rendering unpatentable every compound appearing within.

Enablement and Scanning Electron Microscopes

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Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a 2002 paper, Hla and Reider detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel molecular structures. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last 19 years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the breaking and reforming of bonds within a molecule itself; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality. Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.
>
>
Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a 2002 paper, Hla and Reider detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel molecular structures. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last 19 years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the breaking and reforming of bonds within a molecule itself; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality.

Losing Enablement

Once the manual construction of any sufficiently described molecule becomes technically feasible, enablement is almost certain to become trivial to a person skilled in the technical art. Computer programs that permute and diagram extant molecular structures are scientific reality; an algorithm capable of generating build routines for known chemical structures would likely be even simpler to develop.

Trivial enablement, by itself, is no block to patentability. Many simple mechanical devices are trivial to enable. Molecular structures, however, have the additional property of having a form consisting of a collection of discrete and finite components. The structure of simple molecule, such as H2O? , can be described in detail simply by extrapolating from the basis of its chemical formula. More complex chemical forms have many more possible structural arrangements, and are more difficult to describe; however, techniques for permuting the possible structures of these complex molecules have been developing in the prior art for some time.

The combination of trivial enablement and a finite structure would place chemical compounds in an unique class of material, respective to patent law. Simply by naming a

Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.

 

Other forms of Patent Protection

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 The enablement database would likewise have no effect on production patents – methods of synthesizing or otherwise producing the molecule. Although the particular production steps in the atomic level build routine would be in the public domain, commercially viable methods of manufacturing the molecule would be available for patent protection.
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Neither of these alternate forms of patent protection would be diminished or eliminated by the existence of a public enablement database; however, a public commons could easily be created within a public internet database, simply by adding wiki-like features to the site itself. By providing a place for the posting and discussion of uses...
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Neither of these alternate forms of patent protection would be diminished or eliminated by the existence of a public enablement database; however, a public commons could easily be created within a public internet database, simply by adding wiki-like features to the site itself. By providing a place for the posting and discussion of information surrounding
 

Technical and Legal Issues to be Overcome


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Enablement and Scanning Electron Microscopes

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Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a XXDATEXX paper, XXAUTHORSXX detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel organic molecules. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last XXX years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the _; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality. Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.
>
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Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a 2002 paper, Hla and Reider detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel molecular structures. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last 19 years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the breaking and reforming of bonds within a molecule itself; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality. Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.
 

Other forms of Patent Protection

A database of structures and build routines would have the effect of placing many future compound patents into the public domain. Instructions enabling the individual construction of organic molecules could also be argued to invalidate future “purification” patents on molecules within the database; enabling the construction of an individual molecule would have the effect of enabling (very small-scale) production of purified forms of the compound, and would prevent corporations from later claiming that they had newly purified extant substances.

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The type of enablement database described in this essay would have no effect on two alternative forms of patent protection: the use patent, and the production patent. The use patent provides exclusive rights over a particular use of a compound, regardless of the legal ownership of compound itself. A corporation asserting that it had discovered a new use of a molecule in the database would have the ability to apply for a use patent governing the right to use that particular molecule for that particular purpose. Although use rights are far more limited and difficult to enforce than patents on the compound itself, there is nothing fundamentally ????????
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The type of enablement database described in this essay would have no effect on two alternative forms of patent protection: the use patent, and the production patent. The use patent provides exclusive rights over a particular use of a compound, regardless of the legal ownership status of the compound itself. Although use rights are far more limited and difficult to enforce than patents on the compound itself, there is nothing fundamental to the nature of the database itself that would prevent this type of patent.
 The enablement database would likewise have no effect on production patents – methods of synthesizing or otherwise producing the molecule. Although the particular production steps in the atomic level build routine would be in the public domain, commercially viable methods of manufacturing the molecule would be available for patent protection.
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Neither of these alternate forms of patent protection would be diminished or eliminated by the existence of a public enablement database; however, a public alternative
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Neither of these alternate forms of patent protection would be diminished or eliminated by the existence of a public enablement database; however, a public commons could easily be created within a public internet database, simply by adding wiki-like features to the site itself. By providing a place for the posting and discussion of uses...
 

Technical and Legal Issues to be Overcome


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THIS IS A WORK IN PROGRESS

 

Placing Organic Chemical Compounds in the Public Domain

-- By TheodoreSmith - 18 Oct 2008

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 Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would have the effect of rendering unpatentable every compound appearing within.
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Enablement and Scanning Electron Microscopes

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Advances in the atomic level manipulation of matter have brought modern science to within striking distance of the ability to manually construct novel molecules from their constituent components. In a XXDATEXX paper, XXAUTHORSXX detail the ways in which technicians may manipulate a scanning tunneling microscope (STM) to sever and reform atomic bonds, reposition atoms, and manipulate molecular structures to form novel organic molecules. Although this technology is still in its infancy, the manual construction of molecular compounds is undeniably possible, and one day may become trivial with further advances in equipment and scientific technique. In the last XXX years, the state of the art in atomic manipulation has moved from the painstaking repositioning of Xenon molecules, to the _; it is merely a matter of time before the construction of complex molecular compounds becomes scientific reality. Once techniques for systematically fabricating chemical compounds enter the scientific mainstream, the enablement of any sufficiently well described molecule becomes trivial (or at least may be rendered trivial by the development of a computer algorithm capable of generating enablement steps from chemical diagrams). Once this point is reached, any novel compound could be placed in the public domain simply through public online publication of its chemical structure and build routine; an extensive database of permutations of chemical forms would provide a legal basis on which to invalidate new compound patents.

Other forms of Patent Protection

A database of structures and build routines would have the effect of placing many future compound patents into the public domain. Instructions enabling the individual construction of organic molecules could also be argued to invalidate future “purification” patents on molecules within the database; enabling the construction of an individual molecule would have the effect of enabling (very small-scale) production of purified forms of the compound, and would prevent corporations from later claiming that they had newly purified extant substances.

The type of enablement database described in this essay would have no effect on two alternative forms of patent protection: the use patent, and the production patent. The use patent provides exclusive rights over a particular use of a compound, regardless of the legal ownership of compound itself. A corporation asserting that it had discovered a new use of a molecule in the database would have the ability to apply for a use patent governing the right to use that particular molecule for that particular purpose. Although use rights are far more limited and difficult to enforce than patents on the compound itself, there is nothing fundamentally ????????

 
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Use Patents and Usefulness

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The enablement database would likewise have no effect on production patents – methods of synthesizing or otherwise producing the molecule. Although the particular production steps in the atomic level build routine would be in the public domain, commercially viable methods of manufacturing the molecule would be available for patent protection.
 
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Neither of these alternate forms of patent protection would be diminished or eliminated by the existence of a public enablement database; however, a public alternative
 
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Technical Issues to be Overcome

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Technical and Legal Issues to be Overcome

Many permutations of chemical compounds – could we have in a database, or would an algorithm suffice – mixed so that requesting a molecule would create a permanent entry in a database. Corporations forming their own databases to gain rights (the one case that does not require uses), BUT look at statutory bars and diligence. Alternately, this may allow purification patenting by corporations, and the fact that the use requirement is set so low may lead to a rush of corporate patents before compounds enter the public domain. They would be potentially be able to patent more stuff, but it would be the final rush – 21 years, and all such compounds would be in the public domain.

 

Conclusion

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An economic or moral analysis of this change is beyond the scope of this paper. Chemical compounds have two important characteristics that make them vulnerable to advances: They have a concrete and definite structure – it is more difficult to write an amorphous business method or algorithm style claim to escape the restrictions of prior art, and they are finite in potential size – NEED DATA.

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Placing Chemical Compounds in the Public Domain

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Placing Organic Chemical Compounds in the Public Domain

 -- By TheodoreSmith - 18 Oct 2008
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Introduction

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Chemical compounds are protected under US patent law as "compositions of matter." . Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure and a means of successfully building or synthesizing the chemical; no showing of usefulness is required.
>
>
Chemical compounds are protected under US patent law as "compositions of matter." &lt cite needed &gt. A successful compound patent will provide the inventor with exclusive rights to all uses of that composition (including research) over the life of the patent. Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure of the molecule and "enablement", a means of successfully building or synthesizing the chemical; no showing of usefulness is required. As advances in the material sciences refine techniques for the atomic level manipulation of matter, we are rapidly nearing the point where enablement of a given organic compound becomes trivial; any organic molecule may be constructed from its constituent atoms or pre-synthesized building blocks.

Once this threshold is reached, new organic chemical compounds will become far easier to push into the public domain. Even if such novel compositions are not ruled to be generally unpatentable under the doctrine of obviousness, they will be vulnerable to being placed into the public domain by any individual publishing a sufficiently detailed map of the molecules structure and a simple set of instructions enabling construction of the molecule. The low cost of publishing over the internet paired with the plausibility of algorithmic methods of generating molecular permutations and enablement steps almost guarantee the eventual construction of a database of molecular permutations. This database, showing structure and enablement steps for a wide swath of potential organic compounds, would have the effect of rendering unpatentable every compound appearing within.

 

Enablement and Scanning Electron Microscopes


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Placing Chemical Compounds in the Public Domain

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Introduction

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Chemical compounds are protected under US patent law as "compositions of matter." . Although an inventor seeking a compound patent must show a use for the claimed composition, the same patent may ordinarily be defeated by prior art showing only the structure and a means of successfully building or synthesizing the chemical; no showing of usefulness is required.
 

Enablement and Scanning Electron Microscopes


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Placing Chemical Compounds in the Public Domain

-- By TheodoreSmith - 18 Oct 2008

Table of Contents


Introduction

Enablement and Scanning Electron Microscopes

Use Patents and Usefulness

Technical Issues to be Overcome

Conclusion


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